Time-Resolved Mass Spectrometry : From Concept to Applications.

Intro -- Title Page -- Copyright -- Table of Contents -- Author Biographies -- Preface -- Acknowledgments -- List of Acronyms -- Chapter 1: Introduction -- 1.1 Time in Chemistry -- 1.2 Mass Spectrometry -- 1.3 Time-resolved Mass Spectrometry -- 1.4 Dynamic Matrices -- 1.5 Real-time vs. Single-point Measurements -- 1.6 Further Reading -- References -- Chapter 2: Ion Sources for Time-resolved Mass Spectrometry -- 2.1 Electron Ionization -- 2.2 Chemical Ionization -- 2.3 Atmospheric Pressure Chemical Ionization -- 2.4 Electrospray Ionization -- 2.5 Atmospheric Pressure Photoionization -- 2.6 Desorption/Ionization -- 2.7 Innovations in the 21st Century -- 2.8 Concluding Remarks -- References -- Chapter 3: Mass Analyzers for Time-resolved Mass Spectrometry -- 3.1 Overview -- 3.2 Individual Mass Analyzers -- 3.3 Integrated Analytical Techniques -- References -- Chapter 4: Interfaces for Time-resolved Mass Spectrometry -- 4.1 Molecules in Motion -- 4.2 Time-resolved Mass Spectrometry Systems -- 4.3 Concluding Remarks -- References -- Chapter 5: Balancing Acquisition Speed and Analytical Performance of Mass Spectrometry -- 5.1 Overview -- 5.2 Spectrum Acquisition Speed -- 5.3 Relationship between Spectrum Acquisition Time and Mass Spectrometer Performance -- References -- Chapter 6: Hyphenated Mass Spectrometric Techniques -- 6.1 Introduction -- 6.2 Separation Techniques Coupled with Mass Spectrometry -- 6.3 Ion-mobility Spectrometry -- 6.4 Other Hyphenated Systems -- 6.5 Influence of Data Acquisition Speed -- 6.6 Concluding Remarks -- References -- Chapter 7: Microfluidics for Time-resolved Mass Spectrometry -- 7.1 Overview -- 7.2 Fabrication -- 7.3 Microreaction Systems -- 7.4 Hydrodynamic Flow -- 7.5 Coupling Microfluidics with Mass Spectrometry -- 7.6 Examples of Applications -- 7.7 Digital Microfluidics -- 7.8 Concluding Remarks -- References.

Chapter 8: Quantitative Measurements by Mass Spectrometry -- 8.1 The Challenge of Quantitative Mass Spectrometry Measurements -- 8.2 Selection of Instrument -- 8.3 Solutions to Quantitative Mass Spectrometry -- 8.4 Data Treatment -- 8.5 Concluding Remarks -- References -- Chapter 9: Data Treatment in Time-resolved Mass Spectrometry -- 9.1 Overview -- 9.2 Definition of Terms -- 9.3 Spectral Patterns -- 9.4 Mass Accuracy -- 9.5 Structural Derivation -- 9.6 Molecule Abundance -- 9.7 Time-dependent Data Treatment -- References -- Chapter 10: Applications in Fundamental Studies of Physical Chemistry -- 10.1 Overview -- 10.2 Chemical Kinetics -- 10.3 Chemical Equilibrium -- References -- Chapter 11: Application of Time-resolved Mass Spectrometry in the Monitoring of Chemical Reactions -- 11.1 Organic Reactions -- 11.2 Catalytic Reactions -- 11.3 Photochemical Reactions -- 11.4 Concluding Remarks -- References -- Chapter 12: Applications of Time-resolved Mass Spectrometry in the Studies of Protein Structure Dynamics -- 12.1 Electrospray Ionization in Protein Studies -- 12.2 Mass Spectrometry Strategies for Ultra-fast Mixing and Incubation -- 12.3 Hydrogen/Deuterium Exchange -- 12.4 Photochemical Methods -- 12.5 Implementation of Ion-mobility Spectrometry Coupled with Mass Spectrometry -- 12.6 Concluding Remarks -- References -- Chapter 13: Applications of Time-resolved Mass Spectrometry in Biochemical Analysis -- 13.1 Enzymatic Reactions -- 13.2 Time-resolved Mass Spectrometry in Systems and Synthetic Biology -- 13.3 Monitoring Living Systems -- 13.4 Concluding Remarks -- References -- Chapter 14: Final Remarks -- 14.1 Current Progress -- 14.2 Instrumentation -- 14.3 Software -- 14.4 Limitations -- References -- Index -- End User License Agreement.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.