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008			080709s2008 dcua sb 000 0 eng d
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035			_a(MiAaPQ)EBC3378368
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035			_a(CaONFJC)MIL172680
035			_a(OCoLC)923278949
040			_aMiAaPQ _cMiAaPQ _dMiAaPQ
043			_an-us---
050		4	_aRC270.8 _b.I47 2008
082	0	4	_a362.196/994007 _222
245	0	0	_aImproving the quality of cancer clinical trials _h[electronic resource] : _bworkshop summary / _cNational Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs.
260			_aWashington, D.C. : _bNational Academies Press, _cc2008.
300			_axii, 124 p. : _bill. (some col.).
504			_aIncludes bibliographical references.
505	0		_aIntroduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy.
530			_aAlso available on the World Wide Web.
533			_aElectronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
650		0	_aCancer _xTreatment _zUnited States.
650		0	_aClinical trials.
655		4	_aElectronic books.
700	1		_aPatlak, Margie.
700	1		_aNass, Sharyl J.
710	2		_aNational Cancer Policy Forum (U.S.)
710	2		_aInstitute of Medicine (U.S.)
710	2		_aProQuest (Firm)
856	4	0	_uhttps://ebookcentral.proquest.com/lib/nird-ebooks/detail.action?docID=3378368 _zClick to View
999			_c31076 _d31076